HysterSisters Articles for Hysterectomy
Hyperplasia, Atypia, and Gynecologic (GYN) Cancer
From the GYN Cancer Articles List
SHARING IS CARING
I have been diagnosed with hyperplasia with atypia. Is this cancer or not?
Endometrial hyperplasia is an abnormal overgrowth of the endometrium (lining of the uterus) resulting from prolonged stimulation by estrogen without the proper changes in progesterone levels to trigger regular menstrual bleeding. This causes the endometrium to thicken and become glandular. This is hyperplasia, which may also be a premalignant lesion. In other words: it is not cancer, but it may be a precancerous condition. In about one in four cases, these lesions do become cancerous, so it is certainly something to take seriously.
There are four types of endometrial hyperplasia, some more concerning than others.
Hyperplasia can be either simple or complex. Simple hyperplasia usually refers to the buildup of extra cells in the endometrium without other changes in the structure of the uterine lining. Complex, or glandular, hyperplasia includes both a buildup of cells and the formation of glandular tissue. Women are more susceptible to both forms of hyperplasia during perimenopause, the years just prior to menopause, when menstruation becomes irregular. Post-menopausal women on hormone replacement therapy also have an increased risk for developing hyperplasia.
Atypia refers to the presence of abnormal, possibly precancerous cells in your biopsy. The presence of atypia increases the chance that hyperplasia will develop into malignant tumors.
Simple and complex hyperplasia without atypia together carry just a 3% risk of developing into endometrial cancer. This is about the same risk as a woman without hyperplasia, so hyperplasia without atypia is not considered a precancerous condition. Most gynecologists will recommend treating these conditions with progestin therapy to trigger the sloughing off of the endometrial lining as occurs during regular menstruation.
Hyperplasia with atypia, however, is considered precancerous. The presence of atypical cells means that you and your doctor will want to treat your hyperplasia more aggressively and keep a careful eye on its development. Simple hyperplasia with atypia can be treated with progestin therapy and has a less than 10% chance of developing into cancer. Complex hyperplasia with atypia, though, carries a 25–30% chance of developing into cancer, and in some cases preexisting cancerous cells are detected during treatment. The more advanced and severe the atypia is, the more likely it is to develop into cancer. Many gynecologists will recommend hysterectomy for complex hyperplasia with atypia.
Consult with your doctor and seek a second opinion
if you are unsure about the path he or she is recommending.
This content was written by staff of HysterSisters.com by non-medical professionals based on discussions, resources and input from other patients for the purpose of patient-to-patient support.
08-03-2011 - 02:16 AM
Do you have a question?
If you have a medical support question related to this article, come JOIN US in our HysterSisters Community Forums. You will receive helpful replies to your questions from our members. See you there!
SHARING IS CARING
HysterSisters Free Hysterectomy Booklet
What 350,000 Women Know About Hysterectomy with 50 pages of information, helpful tips and hints as you prepare and recover from hysterectomy through an organized timeline.
Options to Hysterectomy
Hormone and Menopause
Intimacy after Hysterectomy
Fitness after Hysterectomy
Grief and Loss
Ask A Doctor
Recommended for Hysterectomy Recovery
Mesh panties are stretchy and light - perfect for holding peri pads securely during hysterectomy recovery. [...More]
Post-operative compression panty with medical grade silicone to speed hysterectomy recovery + reduce scarring. [...More]
Softest Bra Ever
When you want to wear something, but feel nothing. Two in a value pack for your hysterectomy recovery. [...More]
Find a Surgeon
|Francisco Garcini, M.D.
1870 Silver Cross Blvd
New Lenox IL 60451
|Hugo Ribot, M.D.
958-A Joe Frank Harris Parkway
Cartersville GA 30121
|Katherine Hsiao, M.D.
3905 Sacramento Street, Suite 204
San Francisco CA 94118
|Gerald Harkins, M.D.
Department of OB-Gyn
P.O. Box 850, H-103
Hershey PA 17033
|Kym Boyman, M.D.
1775 Williston Rd., Ste. 110
South Burlington VT 05403
|James Kondrup, M.D.
161 Riverside Drive
Binghamton NY 13905
|Paul MacKoul, M.D.
8218 Wisconsin Avenue
Bethesda MD 20814
|Lillian Schapiro, M.D.
275 Collier Road, Suite 250
Atlanta GA 30309
|Tiffany Jackson, M.D.
601 Clara Barton, Suite 160
Garland TX 75042