HysterSisters Hysterectomy Support and Information
HysterSisters Hysterectomy Support Tutorial

Go Back   Hysterectomy HysterSisters > Hormone Issues (HRT - No HRT) > No Ovaries - Yes HRT - Surgical Menopause

HysterSisters answers for your Hysterectomy Questions With free registration, you can ask and answer questions in our forum community, get free booklets, access Hysterectomy Checkpoints and more. Join us today!

Reply

Vaginal vs. Oral Estrogen Vaginal vs. Oral Estrogen

Thread Tools
  #1  
Unread 01-14-2006, 09:33 AM
Vaginal vs. Oral Estrogen

I found this study on vaginal vs. oral estrogen. It states it is the first known of its kind to test for target organ absorption. Any thoughts or comments? Is it saying that our best option for estrogen absorption is vaginally?

http://www.uscivf.org/pdf/Vaginal%20Estradiol.pdf

and on their ? about progest affecting....
http://www.obgyn.net/newsheadlines/w...0040816-20.asp
  #2  
Unread 01-14-2006, 01:26 PM
Vaginal vs. Oral Estrogen

  Quote:
Is it saying that our best option for estrogen absorption is vaginally?
Noooooooooo, not at all. In the study summarized in the first link, the subjects were given 2mg of estradiol orally or 2mg of estradiol vaginally. The resulting endometrial and serum levels were higher for the ones who used the 2mg vaginally. Well, DUH!!!!

Right off the bat, 95% of the 2mg of estradiol taken orally is lost in the digestive process, so they're down to .05mg, versus 2mg vaginally. Secondly, they measured endometrial tissue concentrations. Well, and how did the estradiol get there? You can be pretty sure most of it did not get there by absorbing into the vaginal walls and entering the bloodstream, traveling throughout the body and somehow magically winding up in a fairly high level in the uterus. It just took the shortcut right up the vagina, through the cervix and there you go! Then it would absorb directly into the walls of the uterus in much the same way it does into the walls of the vagina. It would have been much better if they had used .05mg vaginally (the transdermal equivalent of 2mg oral) and measured tissue levels somewhere else that didn't have a direct connection to the vagina. I suspect that then they would have found that the levels were higher with the oral group because of the low permeability of the vaginal walls.

Of course, imho, I think anyone who would participate in a study which administers 2mg daily of estradiol vaginally and still has a uterus ought to have her head examined... that is a HUGE dose to be using vaginally and unopposed by some form of progesterone or progestin. I wonder how many of those women will wind up with endometrial cancer in 5-10-15 years?

Yes, women who still have a uterus may use a vaginal estrogen like Vagifem or Estring to treat vaginal dryness in natural menopause, but the doses are much, much lower - so low that hardly anything gets past the walls of the vagina. Those products are (imho intelligently) designed precisely with that aim in mind. Vagifem, for example, delivers only 0.025mg of estradiol (1/8 of the dose used in the study) and is typically used twice a week after the initial treatment period.

About the second link... again, it is no big surprise that progesterone would travel right up the vagina, through the cervix and into the uterus much more efficiently than it would get there if taken intramuscularly. That is precisely why, 14 years ago when I was having trouble conceiving because my cycles were too short to allow for implantation (19-21 days), my GYN prescribed natural progesterone vaginal suppositories rather than Prometrium or injections. It's a much more direct route that doesn't rely on the entire body having a very high concentration of progesterone to get the levels up to where they'll do some good in the uterus.

Of course, I don't see where either of these studies is relevant to those of us here who no longer have a uterus... do we care what the endometrial levels would be? No... that's not where our symptoms are coming from.

I'm waiting for research to be done in women who have had a hyst/bso and are using reasonable dosages of bio-identicals for symptom relief.

s,
-Linda
Reply

HysterSisters Free Hysterectomy Booklet
What 250,000 Women Know About Hysterectomy with 50 pages of information, helpful tips and hints as you prepare and recover from hysterectomy through an organized timeline.



Summer Fun Giveaway

Thread Tools

Forum Jump

Similar Threads
From This Forum From Other Forums
5 Replies, Last Reply 11-06-2009, Started By junebugsgarden
3 Replies, Last Reply 07-28-2009, Started By Carolinachick
5 Replies, Last Reply 07-03-2009, Started By littlevixen
1 Reply, Last Reply 06-19-2009, Started By giselle01
3 Replies, Last Reply 02-04-2009, Started By Lou
38 Replies, Last Reply 05-07-2007, Started By lelalo
1 Reply, Last Reply 03-03-2007, Started By Carolinachick
1 Reply, Last Reply 10-16-2006, Started By anne bailey
4 Replies, Last Reply 06-22-2005, Started By jerzeekat_2000
1 Reply, Last Reply 04-06-2004, Started By lou 2
9 Replies, Last Reply 12-17-2003, Started By sunsoaker
9 Replies, Last Reply 07-20-2003, Started By blueridgeartist
2 Replies, Last Reply 02-22-2002, Started By Arebella
2 Replies, Last Reply 12-04-2001, Started By KittenCuddles
7 Replies, Last Reply 11-13-2001, Started By libradoll
16 Replies, Last Reply 10-21-2001, Started By MaryInGa
4 Replies, Last Reply 07-27-2001, Started By Lou
2 Replies, Last Reply 07-09-2001, Started By sherrieb
1 Reply, Hormone and Menopause Central
10 Replies, The Road Less Traveled


Hysterectomy News

September 2,2014

CURRENT NEWS

GYN Cancer - Worry Or Not?
HysterSisters Checking-In September newsletter is now online, providing insight and information about eight (8) GYN canc ... News Archive

TODAY'S EVENTS

Calendar - Hysterectomies - Birthdays


I am a HysterSister

HYSTERECTOMY STORIES

Featured Story - All Stories - Share Yours

FOLLOW US


Your Hysterectomy Date


CUSTOMIZE Your Browsing  


Advertisement


Featured Videos

Dr. Terry answers questions about bone density and oste...

Dr. Rebecca Booth answers many questions about menopaus...

Dr. Rebecca Booth answers questions about menopause....

Dr. Rebecca Booth discusses keeping ovaries with hyster...

HysterSisters App Store Android app on Google Play


Advertisement