It is a good rule of thumb is to give any change a couple of weeks to a month for your body to adjust to the changes and allow the hormones to fully get in your system.
The creams can take alittle more adjusting in the beggining. Where you are applying the creams may help make a difference to the rate of absorption. I have found that the inner thighs work best for my Bi-est cream. When I applied it anywhere else, it absorb much quicker and I ran out of estrogen sooner.
The application sites should be rotated for best results. I use one thigh in the morning and the other thigh in the evening. Also using the Bi-est cream twice a day has helped me tremendously. When I first started I was only applying the full dose in the mornings and found I would feel low estrogen symptoms by evening. So I split the dose in half and use it 12 hours apart. Estradiol goes through our system in approximately 8-12 hours.
I also had to have the strength of my cream adjusted 3 times before I found a dose that worked well for me. It took alot of patience in the beginning, about 6 months for complete balance but I did notice improvement each day. I have been using my hormones in a cream for 3 years and love the ability to adjust them as neccessary.
The progesterone I found works better on areas that are thin skinned such as the upper inner arms. Since this is the first time you are adding the progesterone cream, it may be a good idea to start with just your bi-est for a week and find a dose that you feel good on. Then after you feel pretty balanced with the estrogen, you can add the progesterone.
It can also be helpful to keep a daily journal and learn how your body responds to each of the hormones and which symptoms have improved or which symptoms have become worse.
I know it was helpful for me because I wasn't sure if my anxiety and insomnia were from low estrogen or low progesterone. I used my Bi-est in the beggining and almost all my symptoms went away except the anxiety, low energy, low libido and insomnia. Then I added in the progesterone cream and I started sleeping great and my anxiety attacks vanished.
Then I decided to try testosterone cream for the low libido and energy level. Once those were relatively gone, I knew I found balance.
Here is a link that may be helpful to know what symptoms may be from being high or low in a certain hormone.
You can see from the list that headaches can be from either low estrogen/low progesterone and some women even say they get headaches when their estrogen is high. That is why it is soooo helpful to know which hormones are responsible for each of your symptoms and what dose is best at controlling those symptoms.