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Unread 05-02-2007, 04:13 PM
biest 80/20

Hi Ladies, I have a question, how many women are using biest 80/20, what dose and how many use pill form... And are you using progesterone too. If you are, what syptoms did you have, to tell you that you needed progesterone.. I have more flushing when I use progesterone, and I feel sad... I know we are all different, but I dont know where to start or what my syptoms mean.
If you dont feel well on progeterone what do you use? I dont know if my biest is too strong, I am using biest 70/30, cream, small dose, the doctor said it could be the deliverey, too fast, causing a fearful feeling, then it passes after couple hours, every hour I feel different. I think I need to try pills... please tell me what you are using.. Thanks
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Unread 05-02-2007, 08:16 PM
biest 80/20

I was recently on a dose of 80/20 bi-est. It was 1.25 mg/day in the form of transdermal drops. I had changed to this from Climara. I started having sleep interruptions, dry skin, and hot flashes. We measured my levels and found that either I wasn't absorbing it or that the dose wasn't high enough. I am back on the climara and the flashes and sleep interruptions have disappeared.

I also take progesterone in topical drops. But we are wondering if my skin is absorbing any of it because after taking it for a year, my levels barely showed it AND I don't know that I actually noticed a difference once I started taking it.

My pharmacist theorized that if I can get some progesterone into my system, my body will make better use of the estrogen and maybe the remaining symptoms of irritability, dry skin, saggy breast will normalize. Cross my fingers.

Unread 05-07-2007, 03:38 PM
biest 80/20

Hi JunieK,

If progesterone is causing more flushing, it sounds like the dose is too high. Sometimes too much progesterone causes symptoms of low estrogen. It's hard to sort out symptoms though if we experiment with two hormones at once so it might be easier to work with one at a time. If you were to take estrogen alone, you could adjust the dose until you found the right one. Then you could add progesterone. It sounds slower to do one at a time, but I think it's faster in the long run.

I use an over-the-counter progesterone cream, but I don't feel any differently from it so I can't help with symptoms. I use it because I've read that it helps to balance estrogen.

If you feel different every hour after you apply the bi-est, I think you must be very sensitive to changes in your levels. You might want to try a patch (they are bioidentical estradiol). They give fairly steady levels. They're not 100% steady though, and the levels gradually decrease each day that you wear them. For some women, this is a problem but it's not a problem for everyone. I use a patch called Vivelle-Dot, and I can feel the difference by the last day. But I don't want to discourage you before you even think about it--the patch is still very steady.

If you feel fearful as a side effect, that shouldn't be happening. Maybe the progesterone is involved in some way. Or maybe there's an interaction with another med.

I've never tried bioidentical estrogen pills, but I don't think they give especially steady levels. Pills are digested all at once and they reach the blood stream in a short time span. So our levels increase and then decrease within several hours as the body clears it out. The bio's get cleared out much faster than the synthetics. I think Premarin gives steadier levels than estradiol.
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Unread 05-07-2007, 03:52 PM
biest 80/20

Hi Lilbelle,

Have you ever tried a progesterone cream? Maybe a different base would absorb better. If you decide to try one, it's nice to get them concentrated enough so that you only have to use 1/4 ml. I use an OTC called Oasis Serene, and I apply that amount. It's easy to keep it off your clothes that way.

If you've taken progesterone orally and had benefits, then it seems like an equivalent topical dose would work. There are a couple studies that you can use to compare oral and topical. The comparison is with physiologic effects, not blood levels. Solvay, the drug maker of Prometrium found that 200 mg prevented cell multiplication in the endometrium (1). Helene Leonetti, MD found that 30 mg in a cream did (2). So their ratio is 200:30.
1. Prometrium – Prescribing Information – Clinical Studies (page 4)
2. Leonetti HB, et al. Topical progesterone cream has an antiproliferative effect on estrogen-stimulated endometrium. Fertility and Sterility. 2003 Jan;79(1):221-2. [click for article]
Unread 05-08-2007, 03:39 PM
biest 80/20

I use bi-est (80:20) 3 mg/progesterone 70 mg each day (split dosage morning and night) in gel form. I have endometriosis, and the specialist said the progesterone would help. I just went up from a bi-est 2.5 mg / prog 50 mg.

I have only been on the bi-est/prog for a littl over a month, but I am happy so far!

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