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I've been taking Estrogel 0.06% for the past 7 years now. The research my hubby and I have done indicate that estrogen should only be taken for no more than 5 years to minimize the risk of liver and kidney problems. We're discussing if it's time for me to go off estrogen and risk the power surges and loss of energy to save on problems with liver and kidneys.
Gosh... if I ever went off it, I'd be miserable. But that's me. I've been on it for 27 years (wow - time flies!) and I go in yearly for mammograms and have blood work done at least every 6 months and everything is good. I started out on oral and didn't do well on it. And yes, oral goes thru the liver. I'm now on bio identical creams. IMO - I wouldn't stay on oral estrogen for years.
How do transdermal hormones have an effect on the liver and kidneys? It does not go through the digestive system, it goes to the blood.
I have no plans to stop estrogen, ever. :O)
I think it has less of an effect on the liver and kidneys than oral pills. My reasoning is: your blood is your blood passes thru your liver and kidneys and it does get filtered. Everything we take in has to get broken down and excreted right...
I don't plan on stopping estrogen either though. I am going to try and stay with the transdermals as long as possible.