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Lupron for Endometriosis

From the Endometriosis Articles List

Endometriosis and lupronI have endometriosis and my doctor is recommending Lupron. Should I try it?


Lupron (leuprolide) is a gonadotropin-releasing hormone (GnRH) agonist. It is a synthetic hormone that can be used to create pseudo-menopause and thus theoretically treat endometriosis.

Lupron works by disrupting the signals from the pituitary gland to the ovaries. By causing an overproduction of hormones, it then shuts down the hormonal production altogether. During the initial phase when there is the surge in hormones, women can experience an increase in endometriosis related symptoms and pain. During the next phase, the pituitary gland tells the ovaries to stop producing hormones. As a result, pseudo-menopause should occur from the lack of estrogen. The theory is that with no estrogen from the ovaries, endometriosis will lose its ability to survive and symptoms will then subside. While Lupron is not considered a cure for endometriosis, studies indicate that some women do report an improvement in endometriosis symptoms following its use though.

Lupron can have adverse side effects. Each woman can have a different reaction based on her own body and how it reacts to Lupron. For some, symptoms will be mild. For others, symptoms can be more extreme. Typical side effects can include hot flashes, nausea, headache, weight issues, stop in menstruation, fatigue, and bone loss. Add-back therapy can be given to help with some of the side effects. In general, side effects are reversible though some bone loss may be permanent in some women.

As with other medications, some women love Lupron and others hate it. Each woman must talk to all members of her own medical team to decide if this medication is right for her. Her current health issues (such as migraines, seizures, osteoporosis) and risks for certain conditions have to be considered when determining if Lupron is an option for her.

Do not hesitate to get in touch with your doctors regarding any of your questions or concerns. They should be able to help you understand your symptoms and decide if Lupron would address them effectively and safely. You should also seek a second opinion about what is right for you.


This content was written by staff of HysterSisters.com by non-medical professionals based on discussions, resources and input from other patients for the purpose of patient-to-patient support.

02-06-2013 - 01:40 AM


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