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AGUS / Negative HPV AGUS / Negative HPV

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Unread 02-07-2021, 04:18 PM
AGUS / Negative HPV

Hello ladies, I'm 55 and during my recent pap the results indicated Atypical Glandular Cells of Undetermined Significance (AGUS). The nurse said that it is the lowest of the 5 types of abnormal pap results. However, I am reading you can be HPV negative and still have cancer. There is also a "small" polyp that will need to be removed. My healthcare comes from the VA and my last pap was in 2014 and it was normal. I've been asking for female OB/GYN for years and it was not until last year that a doctor in my local VA can perform a pap. Hence, the above-referenced results. A bit of history is that I'm disabled and was sexually molested as a young woman, my ex-husband was abusive and had many affairs, and I've never had children. I am post menopause and I've never smoked, never participated in drugs, and have not had an alcoholic beverage since the age of 25/26.

I am informed that I'll need to have the polyp removed and a coloscopy. I've had some pain in my lower right back and have attributed that to sciatica nerve pain. I shall have an X-ray soon for the lower back issues and then a consult with a OB/GYN specialist to discuss the polyp removal and coloscopy.

I am reading that 30% to 50% of AGUS are cancerous. Also, that an abnormal AGUS can be other issues as well; yet, not certain what those may be? Can anyone provide that information? Some info is provided in my pap results below; however, I wonder if there is anything else? Like tight jeans or horseback riding?

Can a prior STD from having been molested cause this. The STD has not returned since late my late 20s.

Also, can physical assaults (by ex-husband) and PTSD/depression cause issues?

Below are my pap results:


HPV ASSAY INTERPRETATION: HPV High Risk pool includes twelve types
(31/33/35/39/45/51/52/56/58/59/66/68) and does not include 16 and 18. HPV 16 and 18 are tested separately.

HPV LIMITATIONS OF PROCEDURE: A negative result does not preclude the presence of HPV infection because results depend on adequate specimen collection, absence of inhibitors and sufficient DNA to be detected.

Test Method/Source: ThinPrep Pap/Cervix

Specimen Adequacy: Satisfactory for evaluation; endocervical/transformation zone components present


Endometrial cells are present in woman > 45 years of age (see note).

Note: Endometrial cells in women > 45 years or older may be associated with benign endometrium, hormonal alterations, and less commonly, endometrial or uterine abnormalities. Endometrial evaluation is recommended in postmenopausal women.

Many thanks in advance.

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Unread 02-08-2021, 10:30 PM
Re: AGUS / Negative HPV

Actually, an ASCUS (atypical squamous cells of undetermined significance) result is the most frequent/least concerning of the abnormal pap results. Those can even be caused by such benign things as douching or having relations prior to your exam. Although AGUS paps can also be caused by perfectly benign things, they can be more indicative of a possible pre/malignancy. That's why they require further immediate follow-up in the form of a colposcopy as opposed to simply a repeat pap which is usually the protocol for ASCUS ones. In my case, it was an AGUS pap that led to my cervical adenocarcinoma diagnosis.

I know the waiting is difficult, but you'll have much more information once you've had your upcoming colpo and path on the polyp (which very well could be "just" a polyp!). For now, please try not to let your mind get too far ahead of things, as it always races to the worst case scenarios. And, please don't over-google, especially since you don't know precisely what you're dealing with at this point. Yes, you want to be informed but not overwhelmed. Sending calming hugs and every good thought your way. We're glad you found us!

Unread 02-11-2021, 10:24 PM
Re: AGUS / Negative HPV

Reference infection, it is possible you were (re)infected from your husband having "many affairs" and it is possible you might not have known it. Also, HPV and a couple other things aren't included in some so-called comprehensive STD panels. The VA is notorious for this

Without knowing which STD(s) you contracted when molested or possibly from your husband, don't know if it/they could have caused/contributed to current issues.

BTW, if the VA doesn't have a female OB-GYN at your facility, you have the right to request to see one at the VA's expense in the community. You have to get approval first, and there may be a list of approved providers from which to choose. Contact the Patient Representative to find out who to contact to make this happen.

I am soooooooooooooo sick of how the VA treats female vets for OB-GYN

May God grant you His perfect peace
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Unread 04-05-2021, 07:39 PM
AGUS / Negative HPV

I had a total hysterectomy, ovaries still in place. I'm probably putting the cart before the horse. I need another colposcopy due to still having abnormal cells in the vagina with Hpv 16. What treatments for they do for stuff like this if it's vain 2 or more. Laser? I'm just curious. When will this hpv go away already and quit causing havoc.
Unread 04-07-2021, 09:36 AM
Re: AGUS / Negative HPV

Originally Posted by Kariberries1 View Post
I had a total hysterectomy, ovaries still in place. I'm probably putting the cart before the horse. I need another colposcopy due to still having abnormal cells in the vagina with Hpv 16. What treatments for they do for stuff like this if it's vain 2 or more. Laser? I'm just curious. When will this hpv go away already and quit causing havoc.
Concerning VAIN, if you do a search for VAIN and/or vaginal intraepithelial neoplasia here on our forum, you'll find previous discussions which might be helpful.

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