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rising CA125 during chemo rising CA125 during chemo

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Unread 02-27-2004, 05:51 PM
rising CA125 during chemo

I have just had my 4th session of chemo. Before session 2 my CA125 was 120 (down from 250+ before surgery). Before session 3 the CA125 was 150. I don't have the results before session 4. This bad, right? Has this happened to any one else? I go back in 3 weeks for a doctor's visit. I will have had a pelvic and chest cat scan before the visit. I know he wants to do radiation as well. Will that lower the CA125 as well? I am very scared.


P.S. I had uterine and ovarian cancer. All the biopsy he took of other areas came out OK. They found stray cancer cell in the wash which determined the chemo. I thought my outlook was good but now I am not so sure.
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Unread 02-27-2004, 06:29 PM
rising CA125 during chemo


Ovarian AND uterine cancer at the same time is rare. Is it the same cancer or a spread? Did the doc order chemo sensisitivity tests?

What chemo drugs are you getting?

Unread 02-27-2004, 06:44 PM
rising CA125 during chemo


My cancers were seperate. They were two different types of cancer. The uterine cancer was close to breaking free of the uterus. The ovarian cancer seemed to be contained. I had 4 sessions of carboplatin and taxil. Each three weeks apart. Except between the 2nd and 3rd session was 5 weeks (beccause of low red and white blood cell counts). I never had any sesitivity tests. I haven't really had any major problems with the chemo.
Thanks for listening.

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Unread 02-27-2004, 10:15 PM
rising CA125 during chemo

s cquest

I am only familiar with the treatment of ovarian cancer.
That said, your ca 125 should be falling much more rapidly.
Taxol and carboplatin are the standard chemos used for first line treatment in ovarian cancer. Over 80% of ovca patients will show a good response to these drugs. You might be falling the 20%. If you ca 125 has rises again, you might be a candidate for doxil or topotecan.
Always remember it is time for a second opinion when we start to have doubts.
Are you being treated by a gynecologic oncologist or a medical oncologist that specializes in gyn cancers?
Best wishes to you.

Unread 02-28-2004, 03:44 AM
rising CA125 during chemo

i had to reply to this since i was in the exact same ranges for ca-125..... mine are down to 120 also...i've never heard of them rising during chemo..and THATS scary..I'd ask my oncologist if you haven't already..and the weird thing is I also had uterine/ovarian cancer..and they found stray cells in the wash.... are you sure your're not me? LOL.... please keep us posted am very intersted in this... and I'm going to ask my onco aabout # possibly rising..the only thing I can think of is they may have misread first #... but no worries sweetie..we SHALL be in the 5 yr. survivore club..just hope I've eyebrows by then...hehehehe.........SHZOO
Unread 02-29-2004, 03:52 PM
rising CA125 during chemo

I also had ovarian and uterine cancer. I received 6 rounds of chemo. Taxol and Carboplatin. My Ca-125 was 350 right after surgery. After 1st chemo it was 44, but it was 114 after my second one. At my 3rd it was 19 and then continued to fall. Your last Ca-125 could easily just be a fluke. Definitely talk to your Dr. about this, don't lay around the house worrying about it, you will just get more upset. We are all here for you! I will pray for you!

Let us know your latest results. Take Care!

Unread 03-17-2004, 05:53 PM
rising CA125 during chemo

Hi All,

Just wanted to thank you for all your prayers. My CA125 went down to 58 before the last Chemo (4th). It is now only down to only 50 3 weeks after the 4th Chemo. The doctor is recommending a 5th round next week. My CT scan showed nothing. Another round and we will see what happens. Again thank you for all your prayers.

Unread 03-17-2004, 05:59 PM
rising CA125 during chemo

That is good news quest. I definately know what it is like to have a rise and fall of that controlling number.

Take care and be well.
Unread 03-17-2004, 06:13 PM
rising CA125 during chemo


You had me worried --

I'm doing a happy dance for you

Unread 03-18-2004, 06:50 AM
rising CA125 during chemo

's Judy!

So glad to hear that number is headed in the right direction!


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