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Synarel Vs Lupron Synarel Vs Lupron

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Unread 03-15-2005, 08:11 AM
Synarel Vs Lupron

I am hoping for more comments from those who have been on both drugs.... thanks so much to (((Krinkels))) for your response on my other thread.

I have been on Synarel (twice ... once for 6 months and once for 2 months) and it was OK for me. Side effects were not that bad ... yes, I had some hot flashes and night sweats. Vaginal dryness not that bad, just kept KY with me and used it as needed. Mood was good and after the initial pain flare, things got really better in my pelvis.

Lupron depot has been suggested to me by my gyn and the endo specialist and I am less than enthused. Just wanted to know your experiences for those of you willing to share.


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Unread 03-15-2005, 08:47 AM
Synarel Vs Lupron


I responded on your other thread to clear up my thoughts on Lupron...But wanted to pop in here to let you know that I was put on it back in the 90's. I did my research and didn't like what I was seeing. Both my GP and Gyn (long ago fired) told me I would be fine. When I mentioned my concerns, they said that the side effects happen in a very low percentage of women.

I was supposed to take 6 shots - once per month. I could only get through 3 and even that was a struggle. I was throwing up, my hair started falling out & (for me) it actually made my Endo pain worse. I had a period for over 30 days with severe cramping. When the bleeding stopped, the pain did not go away. Perhaps it was a bit better, but with everything else I was feeling - it wasn't such a 'triumph.' It was also at this time that my joints started hurting so badly that I couldn't sleep. I know I had more reactions to the drug, but I do not have access to my journal at the moment.

Since I have still been having trouble with Endo pain post-hyst., It was suggested that I go on Lupron again. There is no way I will put my body through that again...

I'm sure many more sisters will be along to share their experiences with you - both positive and negative...I know it has done wonders for many, but I certainly wasn't one of them.

Good luck in your research S
Unread 03-15-2005, 09:02 AM
Synarel Vs Lupron


I hear these horrible things about Lupron and wonder if I will get the same sort of response about Synarel. I am so sorry you were put thru this and really appreciate your willingness to share your experience.

My time on Synarel was a snap compared to your experience with Lupron. I had no joint pain, no hair loss and no nausea. I was on a LOT of Tums for calcium replacement and maybe that had a calming effect on my tummy. All things considered, after the initial pain flare, I was greatly improved.

Just makes a gal wonder if although the medicines are the "same" if the inhaled medicine in smaller doses is just better tolerated than the shot?

Take care and thanks again!!!
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Unread 03-15-2005, 06:57 PM
Synarel Vs Lupron

I took two rounds of the Lupron Depot injections and they did carry some major side effects for me. All people are different and respond differently to things....really research, I was so desperate and in so much pain, I am afraid I went in too blind and had lots of problems. My surgeon said the last round did help a slight bit when she operated the 2nd time and finished my TAH. But, if I knew it wouldn't have given me more results, I would not have taken any of them. Research!!!!! Good luck to you and take care!!!! Sorry I couldn't be of any more help. Maybe you could really question your specialist about pros and cons also......
Unread 03-16-2005, 04:40 AM
Synarel Vs Lupron

Hi Michelle!

That is wonderful that you are able to get Synarel at that price. I was looking at my journal when I was experiencing the drug and it had a gradual effect on my body. I slowly felt my endo symptoms disappear and suffered a little discomfort. You are right thinking about the enormous and intense injection of the drug Lupron into our bodies. My body reacted with such force and rejection that I was in ICU with 6 units of blood and flat-lined.

You will know, and only you how much fighting and pain you will take. After my surgery I felt like a loser because I knew I could have fought more with the disease but I had no choice. Please keep us posted and I will pray for some pain relief for you.

Hugs, Cheryl
Unread 03-16-2005, 09:45 AM
Synarel Vs Lupron


I have a call in to my doc to ask him for a Synarel script. Given that its a reasonable cost for me, more reversible and adjustable than a shot and bound to be more gentle than lupron probably would be, I figure I can give the menopause thing a trial run in a way I know I can tolerate fairly well.

If it does not help, then removing my ovaries would probably have been a mistake and perhaps we need to look for other solutions.

Thanks to you all for your caring, compassion and holding my hand thru this.....


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