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Norethindrone (progestin) Norethindrone (progestin)

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Unread 04-15-2006, 06:56 PM
Norethindrone (progestin)

Anyone ever take this stuff?? I had a Lap to remove endo in March, and began taking a daily dose of .35mg of this progestin. Dr. says it should keep endo from growing back till I have surgery in the fall. I feel like ****! But considering I've felt pretty crappy for awhile now, it's hard to tell if it's the hormones, or just me! I'm already on antidepressants, (20mg Lexapro) I have major depression and panic disorder. I've been on the progestin for a full cycle now, and it seems like I started PMSing on schedule, but never stopped. I'm cranky, depressed, have headaches, and absolutely NO energy. Has anyone else been on a progestin drug experienced this?
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Unread 04-15-2006, 07:58 PM
Norethindrone (progestin)

I was given Norethindrone as an addback therapy while taking Lupron a few years ago. I lasted approximately one week on it and that was enough! I had such horrible nausea I couldn't eat, sleep, or think straight. I was also extremely moody and tired. I don't tend to do very well on progestins or even progesterone. I had the same problem on Depo Prevera (also a synthetic progestin) years ago. The moodiness, nausea, fatigue. A few months ago I was given natural progesterone by my gyn (post hyst) to keep the endo at bay and once again the nausea returned, although not as severe. My headaches actually improved on natural progesterone and I slept well for the first time in ages, but the nausea won out in me deciding I couldn't continue with it. Synthetic progestins like Norethindrone do tend to be much stronger in their hormonal effects than natural progesterone. Because they are synthetic hormones they are not exactly like the progesterone our bodies naturally make and can cause unwanted side effects. You may want to ask your doctor about switching to a natural progesterone or trying another synthetic progestin that may not be as harsh for you, or lowering the dose. I do know that too much progesterone can cause depression and somnolence. Since synthetic progestins tend to be stronger and more concentrated so I can imagine what that must be doing to you. At any rate, don't stop taking it until you talk to your doctor. It may just take a while too for your body to adjust to it. I have heard of women doing well on it after giving it several months.

Here are a few threads that women have mentioned Norethindrone on. Hope this helps!
Unread 04-16-2006, 09:15 AM
Norethindrone (progestin)

A high dose of progestin was the only thing that ever worked to stop my extremely painful periods, but I was only allowed to be on it for 6 months at a time. The doc also hoped it would have lasting effects, but it didn't for me - as soon as I stopped taking it, the pain started again.

I felt pretty good on it (relative to feeling like crap without it), just needed a bit more sleep than usual, but I reacted very badly to any estrogen-based treatments, so my hormones may have been different than yours, and that may account for the difference in reaction.

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