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a non-estrogenic solution for hot flashes? a non-estrogenic solution for hot flashes?

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Unread 09-20-2006, 10:38 AM
a non-estrogenic solution for hot flashes?

Hi guys,

I put this on the no-hormone forum but since it's even more critical for women here, I thought I'd post it here too. Not sure how available it is --but I bet a better health food store might have it if it's been sold in Germany for years.

bumped into this one at


Rhubarb Extract May Treat Symptoms of Perimenopause in Women By Jennifer Warner


Researchers found 12 weeks of treatment with a pill containing extract of Rheum rhaponticum, the vegetable more commonly known as rhubarb, significantly reduced the frequency and severity of hot flashes in perimenopausal women.

Researchers say a special extract of rhubarb has been used for many years to treat menopausal symptoms in Germany and elsewhere. The extract, known as ERr 731, doesn’t contain estrogens. It's not entirely clear how ERr 731 performs its actions in the body, write the researchers.

In the study, researchers examined the effectiveness of the rhubarb extract in treating 109 perimenopausal women with frequent hot flashes. About half of the women took a tablet containing 4 milligrams of the rhubarb extract and the other half received a placebo for 12 weeks.

Researchers found a clear decrease in the number hot flashes and symptoms in women who had taken ERr 731. A difference in response to treatment was evident within the first four weeks of treatment with ERr 731 compared with a placebo. For example, on day 28 women taking the rhubarb extract reported an average of 5.5 fewer hot flashes than women in the placebo group, who experienced no decrease.

At the end of the study, women treated with the rhubarb extract also reported improvements in quality of life.

SOURCE: Heger, M. Menopause, September/October 2006; vol 13: pp 744-759.
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Unread 09-20-2006, 10:46 AM
a non-estrogenic solution for hot flashes?

Good info! I used to eat rhubarb pie as a kid. Who knew?!
Unread 09-20-2006, 11:43 AM
a non-estrogenic solution for hot flashes?

Thanks, Trish - I'm taking black cohash (not regularly enough); I still have some hot flashes (having one at the moment). I might look into this. Thanks,
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Unread 09-20-2006, 12:00 PM
a non-estrogenic solution for hot flashes?

It's not entirely clear how ERr 731 performs its actions in the body, write the researchers.
Personally, my thought is that if it helps with menopausal symptoms, it is somehow affecting the estrogen receptors. Until there is information on how it does this, as there is with non-estrogen meds like Tibolone/Livial, for example, I think I'd steer clear of it if you cannot use estrogen at all.

However, I do enjoy rhubarb pie.

Unread 09-20-2006, 02:32 PM
a non-estrogenic solution for hot flashes?

The researchers claim that it's not estrogenic but like any of these herbal remedies the research is limited and a question mark as I indicated is warranted, especially as I did not read the original article. It's in a journal I can't access. And indeed it's not understood if phytoestrogens act as agonists or antagonists and with which receptors. I posted too early in my enthusiasm for a previously unknown possibility.

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