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OTC Progesterone ?? OTC Progesterone ??

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Unread 09-12-2008, 05:05 PM
OTC Progesterone ??

I was in a health food store the other day and was looking at the natural progesterone creams they had. I noticed they had a warning on them about progesterone can cause cancer..the warning was state of CA warning saying it does.
Anyways I always thought it was the estrogen that was the concern about this. Any thoughts, opinions?

Also..what are the main ingredients in OTC progesterone? Is it yams, soy..? What else should I look for, or not want in the creams?

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Unread 09-14-2008, 12:54 PM
OTC Progesterone ??

Hi Ruth That warning, called the Proposition 65 warning after the law that requires it, came about after a review of studies which lumped together natural progesterone with synthetic progestins. Now, as you probably know, the synthetic progestin called Provera was weakly associated with an increase in breast cancer rates in the WHI study in the group of women on Prempro (Premarin plus Provera). Since the study that Prop 65 was triggered by lumped natural progesterone in with Provera (wrongly, imho), natural progesterone became "guilty by association".

If you are looking at buying a natural progesterone cream, you would want to look at the ingredients lists and make sure they state that they contain USP progesterone, at least 400mg per ounce of cream. If they don't say how much, I would not buy them. It doesn't matter a bit whether or not the creams contain soy or wild yams, since our bodies are not able to convert those to progesterone on our own anyway; so most reputable progesterone creams don't contain either one. However, most USP progesterone is synthesized from wild yam sources.

I hope this helps!

Unread 09-15-2008, 03:26 PM
OTC Progesterone ??

Thanks Linda! I've looked at a few OTC creams and some of them do say wild yam or soy, but at least one of them also had the USP on it.? So if it has USP progesterone on label can it have yam or soy listed as ingredients as well? Or not..
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Unread 09-15-2008, 03:29 PM
OTC Progesterone ??

Right. Soy and wild yams have no therapeutic function in creams, but they don't hurt, either. Only the amount of USP Progesterone matters.

Unread 09-15-2008, 03:40 PM
OTC Progesterone ??

Thanks What about ones that contain black cohosh or other stuff like Evening primrose oil? Good or bad?? Especially since it's all additives/extras and not sure if allergic or not.

Have you heard or read anything about grapefruit or the juice, bad or good when it comes to using progesterone? I read something somewhere and now can't remember where. I hate it when I can't remember something. ha
Unread 09-15-2008, 03:55 PM
OTC Progesterone ??

Hi Blondie, I've been reading a few of your entries and wanted to chime in. I am 8 months post op and tried to go without ERT because of family history and I had endo. I made it 10 weeks! My gyn/onc. suggested waiting to see how I did as up to 25% of women won't have horrible symptoms. She also said just not feeling good was reason enough to take ERT. She would have prescribed for me but I was released from her care at 3 weeks (she thought a year on ert and then start weaning down) and my reg. gyn. started me on the Vivelle Dot .05 (she said 5 years on ERT). My GP thought 7 years and see how you feel. My GP has recently upped my dose to .1 and I switched to Climara to see if it would help with anxiety (yes) and hair loss (who knows). It really became about quality of life for me. I could take the hot flashes but not the insomnia and anxiety. I am doing so much better now.

In regards to progesterone I tried Femgest and it didn't do much. It says progesterone on the label but not USP. I then tried Progest and could tell that was doing something. I asked my GP and she was okay with me trying it. I haven't used it for a while now. I may try again but for now I'm feeling pretty good. It is important to get your estrogen dose right first. At least that's what I've learned from the wonderful ladies here!

I wish you the best in your decision and truly know how hard it is!

Take Care,

Unread 09-15-2008, 04:18 PM
OTC Progesterone ??

Hey Blondie,
Have you looked at the creams that are for sale on this site?
Hang in there!
Unread 09-15-2008, 04:55 PM
OTC Progesterone ??

I'm hoping to be as fortunate as my next door neighbor. She had her total hyst 2 years ago and isn't taking anything except OTC progesterone. No hot flashes or anything..
I feel a little warm at times, not bad. I'm still hoping I won't get the bad hot flashes, heart palitations, and such because I think it will cause me to have more panic attacks/anxiety. But if it gets bad more than likely will try something. I just worry about side effects from hormones a lot.

Hi Freezy, yes I've looked at the cream here and a few others. I've been trying to compare all of them and see what would be best.
Unread 09-15-2008, 05:14 PM
OTC Progesterone ??

(((blondie))) did your friend who had the hyst also have her ovaries removed? That would be fortunate, indeed, as most of us without ovaries do NOT get symptom relief from progesterone alone. Perhaps she was already close to natural menopause, if she did indeed have her ovaries out?

I would stay away from creams that contain phytoestrogens like black cohosh because they can interfere with your estrogen replacement. There are plenty of creams that do not contain them that you could use.

The issue with grapefruit juice has to do with estrogen replacement, not progesterone. Grapefruit is contraindicated with estrogen.

Unread 09-15-2008, 05:42 PM
OTC Progesterone ??

Yes she had her ovaries removed too. She was 45 at the time. She thinks a lot of her trouble was from too much estrogen/dominant before surgery.

Thanks for clearing up the grapefruit issue. Not sure why I thought it was progest, probably from reading so much about it lately. ha

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