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Gemzar/Carboplatin - Any experiences? Gemzar/Carboplatin - Any experiences?

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  #1  
Unread 07-08-2009, 09:35 PM
Gemzar/Carboplatin - Any experiences?

My CA125 has spiked up to 128, and I had a CT scan last week that showed no disease. I will have a PET scan next week, and I will probably start on a six month chemo consisting of Gemzar/Carboplatin.

I would like to hear your stories about this chemo combination.

Thanks so much!
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  #2  
Unread 07-09-2009, 01:23 AM
Re: Gemzar/Carboplatin - Any experiences?

I'm so sorry you even have to think about this again.

I'm on Gemzar/cisplatin for the second time. So, yes, I have lots of experience with Gemzar and a related platinum-based drug..

Gemzar makes me hungry. I eat something every 2-3 hours. Thsi doesnt' happen to everyone though.

After 4 or 5 rounds I developed a metallic taste in my mouth that made food selection a bit tricky. This time they told me to try zinc lozenges to help counteract that, but so far it hasn't started again. (I'm only on round 2)

Gem hits the bone marrow pretty hard and also tends deplete ptassium and magnesium. I did fine with adding K and Mg rich foods to my diet, plus what they gave me IV. I was on Neulasta (neupogen this time) and Aranesp most of the time. My platelets dropped a lot initially adn then recovered and were OK the rest of the time.

They say Gemzar usually casues hair thinning but not ususally loss of all your hair. First tiem around I'd already lost my hair on Taxol, butit did strt growing back while I was on Gemzar. This time, it's thinning alright. I'm wondering if I'm going to have to dust off my wig.

That's all I can think of right now. It's late and I had a rough day at chemo. If I thnk of anythign else I"ll post again. If there's anything else you'd like to know, ask away.
  #3  
Unread 07-09-2009, 08:37 PM
Re: Gemzar/Carboplatin - Any experiences?

No experience BlueArtemis - but I am also so sorry that you have to think about this again.

Please, let us know what the PET scan shows. Maybe they will decide chemo won't be needed? There is always that chance...

Hang in there
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  #4  
Unread 07-10-2009, 07:43 AM
Re: Gemzar/Carboplatin - Any experiences?

Thanks, everyone. My doctor told me I would not lose my hair on Gemzar, and now I am worried! I am sure I will have to take Neulasta, too. Wolfie, the doctor wants me on chemo no matter what he finds on the PET scan. He is very aggressive. On the PET scan he will be looking for tumors that can surgically be removed. He says sometimes they are hiding in the spleen and cannot be seen on a CT scan. I tried to talk him into letting me get off all treatment and let fate happen, but he convinced me to continue treatment. My son insists on that, too.
  #5  
Unread 07-10-2009, 10:35 AM
Re: Gemzar/Carboplatin - Any experiences?

  Quote:
Originally Posted by BlueArtemis View Post
Thanks, everyone. My doctor told me I would not lose my hair on Gemzar, and now I am worried! I am sure I will have to take Neulasta, too. Wolfie, the doctor wants me on chemo no matter what he finds on the PET scan. He is very aggressive. On the PET scan he will be looking for tumors that can surgically be removed. He says sometimes they are hiding in the spleen and cannot be seen on a CT scan. I tried to talk him into letting me get off all treatment and let fate happen, but he convinced me to continue treatment. My son insists on that, too.
I wouldn't worry too much about the potential hair loss. I have the added hair loss probablility from cisplatin. And I take into acccount that my body is really reactign strongly to these drugs this second time around on them. I don't know if carbo affects hair loss or not. Given my allergic reaction to cisplatin on Wednesday, I may be switched to carbo next week, so we'll see how that goes.

All in all, Gem/cis was much easier than Taxol/carbo in my experience.
  #6  
Unread 07-10-2009, 12:28 PM
Re: Gemzar/Carboplatin - Any experiences?

Sis,

I noticed you were on Tamoxifen. Did it help you at all? I was on it, and my ca125 kept rising gradually. Then it spiked....to 128.

I am glad to hear that this regimen is not as bad as carbo/taxol. That was difficult for me.
  #7  
Unread 07-11-2009, 01:35 AM
Re: Gemzar/Carboplatin - Any experiences?

  Quote:
Originally Posted by BlueArtemis View Post
Sis,

I noticed you were on Tamoxifen. Did it help you at all? I was on it, and my ca125 kept rising gradually. Then it spiked....to 128.

I am glad to hear that this regimen is not as bad as carbo/taxol. That was difficult for me.
Whether it helped me or not is unknown.

My CA125 was 40 post-op and 19 when I finished chemo. After several months it started a slow rise to around 43, where it leveled off and stabilized. We had planned to wait until it rose a bit more and see if Tamoxifen would affect the results, but once it was stable on its own for a while we decided to go ahead with the Tamoxifen, hoping it would maintain the stability, even though we couldn't monitor effectiveness as well as we had hoped to.

My CA125 remained stable for nine months and then spiked to 100, and I had a cyst-like lesion in my pelvis. My gyn/onc decided it was defintitely a recurrence. Long story short - my new gyn/onc agreed it most likely was a recurrence, buthe wantd more scans adn testign before he'd write me off as done for. A couple of months later, following more scans and labs, the lesion was gone and my CA125 dropped backed down. It was termed a spontaneous remission. I prefer to declare it a miraculous remission.

This recurrence was discovered in January of this year (CA125 was 156 and I had a liver met). I went off the Tamoxifen several weeks before my surgery in late March, primarily to have the tumor unaffected by any suppression effects so we'd get a better growth prospects when they cultured it for chemosensitivity testing.

So, maybe it helped keep me stable. Maybe not.
Maybe it was significant in my spontaneous remission. Maybe not.
  #8  
Unread 07-11-2009, 02:50 PM
Re: Gemzar/Carboplatin - Any experiences?

Sis,

I understand the unknowns of all this and the maybe/maybe nots. It is really a game and a gamble. I like the idea of the miraculous remission!

Thanks to all of you for being there. You are the only folks I trust when it comes to this subject.

Big hug,
Krista
  #9  
Unread 08-21-2009, 12:24 AM
Re: Gemzar/Carboplatin - Any experiences?

I am still recovering from my second surgery on July 30. I am pretty weak. My blood counts are all borderline. The plan is to start me on the Gemzar/Carboplatin next week. I am still interested in any experiences.

My cells were sent off to be analyzed for chemo sensitivity, but that report is not back yet.

The doctor did mention that I could take Taxol/Carboplatin again, but I really did not want to go there again. I am ready to try something new.

Thanks for listening.
  #10  
Unread 08-21-2009, 11:40 AM
Re: Gemzar/Carboplatin - Any experiences?

(((Blue)))

I am sorry that your recovery has not been as quick and easy as mine was I'm sorry if I misled you with my experience.

Good luck with the Gemzar combo. Please let us know how it goes!
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