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Can Oral Estrogen HRT cause optic nerve infammation? (2012) Can Oral Estrogen HRT cause optic nerve infammation? (2012)

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  #1  
Unread 05-20-2012, 03:11 PM
Can Oral Estrogen HRT cause optic nerve infammation? (2012)

I was taking estradiol 2mg for 3 weeks and had a sudden onset of a blurriness to one portion of my vision in my left eye. I was told by my OB GYN to stop the estradiol after seeing an Opthalmologist who diagnosed my condition as optic neuritis in the left eye, cause undetermined at this time. Both agreed to stop the estrogen to see if the blurred area clears up in a week or two. I understand that estrogen can affect the absorption of vitamin B6. Is that just oral estrogen that can interfere with getting enough B6? I really prefer not to go without estrogen since I am only 47 and I want to maintain my youthful appearance and avoid the symptoms of menopause. My eyes are still 20/20. I am hoping this annoying blurry spot resolves on its own, I do value my eyesight. Would a cream or patch cause the same issue if the oral estradiol is determined to be the culprit?
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  #2  
Unread 05-23-2012, 10:07 AM
Re: Can Oral Estrogen HRT cause optic nerve infammation?

I hope your condition has cleared up since you stopped your estrogen. I am not sure if estradiol in another form would be safe to take or not. I would listen to my doctor for advice and treatments.

  #3  
Unread 05-23-2012, 02:39 PM
Re: Can Oral Estrogen HRT cause optic nerve infammation?

No improvement so far. Estradiol was stopped as of Friday. We are now 5 plus days without estradiol. I do not know how long the fat cells store estrogen once you stopp HRT. No hot flashes experienced yet. The blurry spot in the left eye has not resolved yet. Ibuprofen does little or nothing to lessen the blur. The suggestion was to take the anti inflammatory Ibuprofen (Advil or Motrin since they reduce nerve inflammation) to maybe improve the vision by reducing the swelling. So far, no difference. My one week follow up appt is tomorrow morning with the Opthalmologist. I am not optimistic. What a no win trade off. Get rid of a huge fibroid tumor riddled uterus and cystic ovaries and lose the fantastic 20/20 clear vision in my left eye. Really starting to get depressed at the thought this is the way it is going to be, or worse. Husband keeps making light of it which really stinks and makes me feel totally alone. He just doesn't get it.
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  #4  
Unread 05-23-2012, 05:40 PM
Re: Can Oral Estrogen HRT cause optic nerve infammation?

  Quote:
Originally Posted by reiner fan View Post
No improvement so far. Estradiol was stopped as of Friday. We are now 5 plus days without estradiol. I do not know how long the fat cells store estrogen once you stopp HRT. No hot flashes experienced yet. The blurry spot in the left eye has not resolved yet. Ibuprofen does little or nothing to lessen the blur. The suggestion was to take the anti inflammatory Ibuprofen (Advil or Motrin since they reduce nerve inflammation) to maybe improve the vision by reducing the swelling. So far, no difference. My one week follow up appt is tomorrow morning with the Opthalmologist. I am not optimistic. What a no win trade off. Get rid of a huge fibroid tumor riddled uterus and cystic ovaries and lose the fantastic 20/20 clear vision in my left eye. Really starting to get depressed at the thought this is the way it is going to be, or worse. Husband keeps making light of it which really stinks and makes me feel totally alone. He just doesn't get it.
T......

Hi there.

I had my TAH/BSO on January 30th, am having a great recovery. Started .05 estrogen patch in late Februrary and on May 10th, I was diagnosed with optic neuritis.

I have MS, though, and this is considered a relapse--my first in 7 years.

What they have done for me is give me 5 days' of intense steroid infusions with a home health nurse. The explanation is that the stress of the surgery and the immune response afterwards may have triggered my ON. I have no vision in my right eye now, and I am sure you know how unsettling (understatement) that is.

Many MS cases start with a case of ON. Has your doc mentioned that? They don't diagnose MS until the patient has had 2-3 exacerbations, and they do MRI,

Wishing you luck--it should turn around, although you have raised an interesting pointvabout estrogen. Maybe it's lack of progesterone that is doing this to us?

As for the men in our lives: I know how they can sometimes hurt our feelings.. For sure.. Because they don't respond as we would if the sitch were reversed. I view it as their coping mechanisms. If they can make light of it a bit, it keeps them moving ahead and taking care of their half of our life together, great. At least we both aren't falling apart.
  #5  
Unread 05-30-2012, 10:16 PM
Re: Can Oral Estrogen HRT cause optic nerve infammation?

Hi KatNir,

I admire your coping skills. I am so sorry that you had a relapse. I am very scared about the optic neuritis and what it could be a sign of. MS was in fact mentioned as a possibility by the Opthalmologist on May 17 when he first examined my left eye problem. I have no one in my family with MS. As best I know I have never had any prior issues or symptoms that are associated with MS and I am 47. Certainly, there were no prior issues with my eyes. I am coordinated, have no balance problems and have no nerve issues with my arms or legs. My Opthalmologist admitted last week at the last check up that he did some more research and found that estrogen imbalance can cause papilledema.... which is optic neuritis. I go to see him again in the morning for another status check of both eyes and both optic nerves to see if the left nerve shows any signs of improvement and to make certain the right eye looks fine. Based on what I can tell, there is no change in the vision problem. A Neurologist will see me on Monday. We will discuss the causes and see where we go from there. Thank you for your good wishes. I sincerely wish you continued strength and a relapse of your MS.
  #6  
Unread 05-30-2012, 10:46 PM
Re: Can Oral Estrogen HRT cause optic nerve infammation?

  Quote:
Originally Posted by reiner fan View Post
Hi KatNir,

I admire your coping skills. I am so sorry that you had a relapse. I am very scared about the optic neuritis and what it could be a sign of. MS was in fact mentioned as a possibility by the Opthalmologist on May 17 when he first examined my left eye problem. I have no one in my family with MS. As best I know I have never had any prior issues or symptoms that are associated with MS and I am 47. Certainly, there were no prior issues with my eyes. I am coordinated, have no balance problems and have no nerve issues with my arms or legs. My Opthalmologist admitted last week at the last check up that he did some more research and found that estrogen imbalance can cause papilledema.... which is optic neuritis. I go to see him again in the morning for another status check of both eyes and both optic nerves to see if the left nerve shows any signs of improvement and to make certain the right eye looks fine. Based on what I can tell, there is no change in the vision problem. A Neurologist will see me on Monday. We will discuss the causes and see where we go from there. Thank you for your good wishes. I sincerely wish you continued strength and a relapse of your MS.
---

Are you working?

The neurologist may want an MRI. Not a bad thing.

How are your nerves? Any anxiety?

K.
  #7  
Unread 05-31-2012, 11:32 AM
Re: Can Oral Estrogen HRT cause optic nerve infammation?

Kathie,

I expect to be released to return to work sometime next week after my OB GYN follow up and the neurologist appointments which are on 6/04. I am still within my 6 week recovery window at present, so I am not yet back to work.

I have anxiety when I dwell on the possible causes behind the optic neuritis. I am usually pretty laid back and calm about things. I tend to be a pragmatist rather than a panicker, but like everyone, eyesight is very precious and the thought that it is threatened by yet an unknown cause can get the anxiety meter to register.

Regarding the hormone issue. I am told that the eye has estrogen receptors so I think the possible link between ON and hormone imbalance is estrogen not progesterone. However, progesterone modifies estrogen in that the more progesterone in your body, the estrogen effects are reduced. The short lived progesterone spike is what causes your cycle to trigger.

Since my max out of pocket is satisfied for 2012, I have no reason to delay an MRI if the neurologist orders it. I just want to know what the cause is so I can deal with it.

How are you? Are you working or on disability? When did your optic neuritis episodes start? After your first two or three bouts with your ON did the vision come back completely? Was it always your right eye, or did it vary as to which one got the ON or both at the same time?

Sending you hugs from Texas.
  #8  
Unread 06-01-2012, 11:46 PM
Re: Can Oral Estrogen HRT cause optic nerve infammation?

  Quote:
Originally Posted by reiner fan View Post
Kathie,

I expect to be released to return to work sometime next week after my OB GYN follow up and the neurologist appointments which are on 6/04. I am still within my 6 week recovery window at present, so I am not yet back to work.

I have anxiety when I dwell on the possible causes behind the optic neuritis. I am usually pretty laid back and calm about things. I tend to be a pragmatist rather than a panicker, but like everyone, eyesight is very precious and the thought that it is threatened by yet an unknown cause can get the anxiety meter to register.

Regarding the hormone issue. I am told that the eye has estrogen receptors so I think the possible link between ON and hormone imbalance is estrogen not progesterone. However, progesterone modifies estrogen in that the more progesterone in your body, the estrogen effects are reduced. The short lived progesterone spike is what causes your cycle to trigger.

Since my max out of pocket is satisfied for 2012, I have no reason to delay an MRI if the neurologist orders it. I just want to know what the cause is so I can deal with it.

How are you? Are you working or on disability? When did your optic neuritis episodes start? After your first two or three bouts with your ON did the vision come back completely? Was it always your right eye, or did it vary as to which one got the ON or both at the same time?

Sending you hugs from Texas.
Hi there.

I have been working, thanks to carpooling. All the while, my worry pot simmers and I am happy with the distraction. I am a VP of human resources.

My ON was in one eye first ten years ago (the right), in both eyes 7 years ago, and now in right eye. My vision never fullly recovered after my second bout, but it was essentially good--with the glasses I wear. (near-sighted since I was 5). This recent bout started 25 days ago...3.5 months after my surgery, 2.5 months after going on the .05 patch. I have never lost all vision before.


I tend towards anxiety, although I am maintaining well.

My neuro-opthalmologist took my estrogen question and searched medical journals for the last 25 years and found three articles that explored this idea, but the findings were not overwhelming. But, don't some estrogen Rx info sheets list eye changes as a rare side effect?

How long have you had your ON?

Did you tell me how old you are?
  #9  
Unread 01-08-2015, 03:28 AM
Re: Can Oral Estrogen HRT cause optic nerve infammation?

I'm opening this thread back up in hopes to hear how you Ladies are doing. I am going thru the same thing. I noticed my right eye start to blur thrvday after surgery. That is when my Dr put a patch on me. My eye continued to get more blurry but blew it off to the meds and surgery. After a more or so I knew it was from the estrogen. Now have optic nerve damage in my right eye, with bad vision almost cloudy. Going to different specialists. And Casey eye institute. They all tell me that the consumer info on estrodial and vision blindness should be more than just a warning on their pamphlet or label. The specialist all recommend going off estrodial for awhile to see if any eyesight at all will be reversible. Totally not worth having glaucoma over at all. Just wanted everyone out there to know to watch for any vision changes at all. Prayers are welcomed as I'm very upset and nervous as you can imagine. Thank you , and please be aware. 💜
  #10  
Unread 01-08-2015, 03:46 AM
Re: Can Oral Estrogen HRT cause optic nerve infammation?

It is a side effect on any form of estrodial.
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