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Fibroid alternatives...Lupron? Fibroid alternatives...Lupron?

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Unread 06-30-2000, 10:34 AM
Fibroid alternatives...Lupron?

I have been advised by my doctor that a hysterectomy is my best alternative for my large fiboid. (Size of 18 week pregnancy, on the outside of my uterus, and attached really well -- making a myomectomy dangerous.)
He did bring up the Lupron option to put me into temporary menopause, and hopefully to shrink the fibroid. He isn't too hopeful that it will work, since a six month period of breastfeeding (which also supresses the estrogen) didn't cause any shrinkage at all.
Is there anyone here who has tried Lupron for fibroids?
How did it work? I would hate to try it, and mess up all my hormones if I'm just going to end up with a hysterectomy anyways. I just think that I should investigate my options well. (I also have to switch doctors due to insurance changes, so that will give me an automatic second opinion.)
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Unread 06-30-2000, 11:38 AM
Fibroid alternatives...Lupron?

Welcome, NewMom!

I've had two Lupron shots as a pre-op measure for a supracervical laporoscopic hyst. (If you're interested in what that is, check the website below for some info. Basically the hyst is performed thru a lap incision, leaving the cervix and ovaries, and resulting in fewer post-op symptoms and faster recovery.)

Now to your question. I'll quote from the package insert under indications and usage "Uterine Leiomyomata (Fibroids): LUPRON DEPOT 3.75 mg concomitantly with iron therapy is indicated for the preoperative hematologic improvement of patients with anemia caused by uterine leiomyomata. The clinician may wish to consider a one-month trial period on iron alone inasmuch as some of the patients will respond to iron alone (see clinical trial results). LUPRON may be added if the response to iron alone is considered inadequate. Recommended duration of therapy with LUPRON DEPOT 3.75 mg is UP TO three months." Under administration: "Recommended duration of therapy with LUPRON DEPOT 3.75 mg is UP TO 3 months. The symptoms associated with uterine leiomyomata will recur following discontinuation of therapy. If additional treatment with LUPRON DEPOT 3.75 mg is contemplated, bone density should be assessed prior to initiation of therapy to ensure that values are within normal limits." and under precautions "Patients should not use LUPRON DEPOT if they are pregnant, breast feeding, have undiagnosed abnormal vaginal bleeding, ...."

In other words, yes your broids may shrink, but they will grow back - on average in 8 months. The company manufacturing Lupron does not recommend, in their package insert, using Lupron for treatment of fibroids other than as a pre-operative measure.

OK. My symptoms since being on Lupron. Mostly positive. Bladder pressure is gone, lower back pain is gone, tummy is flatter, and basically I do think little Fiberina (my biggest broidie baby) and the twins are shrinking like the wicked witch of the west. I would, personally, never have risked the risks of Lupron if I were not scheduled for the lap hyst. It has, however, given me a preview (I hope) of post-op me - and I like it. I even had a pain-free period soon after my first shot. THAT was pretty unreal! (Altho, of course, I won't have ANY periods post-op, or if I do, just light spotting since they're leaving my cervix.

Phew - long answer - hope it helps. Be sure to roam around on the pre-op board and the pull-down menus too - and let us know how you are. Keep asking questions. HysterSisters are the best!

Det. Dixie Tracy, Fibroid Investigator (aka Diana)

[Edited by Dixie Tracy on 06-30-2000]
Unread 06-30-2000, 01:16 PM
Fibroid alternatives...Lupron?


Dixie is right. Lupron is a short-term fix only. It can be useful in shrinking fibroids before surgery but you cannot take it forever. You have to come off of it and then they can grow back. Your comment that you would hate to mess up your hormones and end up having a hyst anyway makes us think that perhaps you thought that you can take Lupron instead of having a hyst. If you and your doctor have decided that you need a hyst to get rid of the fibroids, the Lupron may help shrink them before surgery but you will probably end up with the hyst in the long run - the Lupron will just delay it and maybe make it easier for your MD if the fibroids are smaller at the time of surgery, Listen to Dixie - she is the Fibroid Investigator , and then talk toy our MD about what his goals are for you in terms of Lupron therapy. Good luck and let us know what happens.
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Unread 06-30-2000, 02:21 PM
Fibroid alternatives...Lupron?

Thanks, ladies! You are right, I did think that the Lupron would be a longer lasting solution. I haven't called my doctor with all my questions because his group dropped my HMO, so I am going to have to switch to a new doctor. I guess I will be getting a second opinion that way...
My fibroid is in the back, so I'm not having the bladder symptoms too much (at least I don't think so... I'm so much better than when I was pregnant AND had the fibroid last November, but I still could be abnormal...)
It's nice to "talk" with other women who are going through the same things I'm going through.

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